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With more than 7,500 known cultivars for temperate and subtropical climtes, the apple (Malus domestica, Rosaceae) is one of the most widely cultivated tree fruits. Usually propagated asexually by grafting, the most important commercial cultivars combine desired qualities including fruit shape, skin color, flavor, absence of russeting, disease resistance, ease of shipping, extended storability and high yields. We provide information about the numerous aspects of production of apples including cultivation, pests and diseases, harvest, postharvest and storage.