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Research > Chapter 10025



Bookmarks

Unique Floral Structures Iterative Evolutionary Themes Asparagales - Insights Morphological Cladistic Analysis

Unique HLA antigen frequencies Finnish population

Unique Holoenzyme Dimers Tetrameric Enzyme Escherichia coli Methylenetetrahydrofolate Reductase - Characterization Structural Features Associated Modulation Enzyme's Function

Unique Physicochemical Profile b-Amyloid Peptide Variant Ab1-40E22G Protofibrils - Conceivable Neuropathogen Arctic Mutant Carriers

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing

Unique Structural Characteristics Peptide Deformylase Pathogenic Bacterium Leptospira interrogans

Unique Structural Features That Influence Neutrophil Emigration Into the Lung

Unique Tertiary Neighbor Interactions Determine Conservation Patterns Cis Watson-Crick A/G Base-pairs

Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide

Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase

Unique Conserved Features Genome Proteome SARS-coronavirus, Early Split-off From Coronavirus Group 2 Lineage

Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development

Unique conserved aspects gut progress zebrafish

Unique independent parameters (UIP) formulation thermodynamic models complex protein-ligand systems

Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis

Unique redundant connexin contributions lens progress

Unique aspects of cytoplasmic male sterility and fertility restoration in Brassica napus

Unique astrocyte ribbon adult human brain neural stem cells lacks chain migration

Unique behavior Dictyostelium homologue TRAP-1, coupling differentiation D. discoideum cells

Unique binding synthetic inhibitor, N-(3-(4-(4-(amidinophenoxy)carbonyl)phenyl)-2-methyl-2-propenoyl)-N-allylglycine methanesulfonate, bovine trypsin, revealed crystal formation complex

Unique binding site Mn2+ ion responsible reducing oxidized YZ tyrosine manganese-depleted photosystem II membranes

Unique cholesteryl glucosides in Helicobacter pylori: composition and structural analysis

Unique chromatin remodeling transcriptional regulation spermatogenesis

Unique chromosomal regions associated with virulence of an avian pathogenic Escherichia coli strain

Unique conformation of cancer autoantigen B23 in hepatoma: A mechanism for specificity in the autoimmune response

Unique endothelin receptor binding kidneys ETB receptor deficient rats

Unique environment Trp48 Pseudomonas aeruginosa azurin probed site-directed mutagenesis dynamic fluorescence spectroscopy

Unique epitope apolipoprotein A-I expressed pre-b-1 high-density lipoprotein function catalyzed efflux cellular cholesterol

Unique expression of a highly conserved mycobacterial gene in IS901+ Mycobacterium avium

Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

Unique features of fowl adenovirus 9 gene transcription

Unique fold active site cytomegalovirus protease

Unique forms of human and mouse nuclear receptor corepressor SMRT

Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease

Unique ligand-protein interactions truncated hemoglobin Mycobacterium tuberculosis

Unique localization mRNA encoding plasma membrane Ca2+ pump isoform 3 rat thin descending loop Henle

Unique locomotory mechanism Mermis nigrescens big nematode crawls soil climbs vegetation

Unique mechanism inhibition Na+-amino acid cotransport chronic ileal inflammation

Unique mitochondrial genome architecture in unicellular relatives of animals

Unique molecular surface features of in vivo tolerized T cells

Unique morphology human eye

Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains

Unique organization and regulation of the mrx fimbrial operon in Xenorhabdus nematophila

Unique permeability barrier of the apical surface of parietal and chief cells in isolated perfused gastric glands

Unique physicochemical properties human enteric Ad41 responsible survival replication gastrointestinal tract

Unique physiological pathogenic features Leptospira interrogans revealed whole-genome sequencing

Unique progressive cleavage mechanism HIV reverse transcriptase RNase H

Unique properties core bacteriophage f8 virus segmented dsRNA genome

Unique protein database imperiled

Unique push-pull mechanism dealkylation soman-inhibited cholinesterases

Unique regulation anion/HCO3- exchangers constitutive nitric oxide rabbit intestine

Unique regulation of carbohydrate chemotaxis in Bacillus subtilis by the phosphoenolpyruvate-dependent phosphotransferase system and the methyl-accepting chemotaxis protein McpC

Unique regulatory properties of the type 2a Ca2+ channel b subunit caused by palmitoylation

Unique answer pathways established allosteric interactions nuclear hormone receptors

Unique targeting cytosolic phospholipase A2 plasma membranes mediated NADPH oxidase phagocytes

Unique three-repeat sequences FVa, LVb/C4, CORE motifs LTR-U3 Friend murine leukemia virus clone A8 accelerate induction thymoma rat

Unique tissue-specific degree DNA nucleotide excision repair primary human mammary epithelial cultures

Unique type II topoisomerase mutant hypersensitive broad range cleavage-inducing antitumor agents

Unique, all-taxa survey Costa Rica self-destructs

Uniquely conserved non-translated regions involved generation major transcripts protein phosphatase 2Cb

Unisexual Clones - Lizards Corals

Unitary Ca2+ Current through Mammalian Cardiac and Amphibian Skeletal Muscle Ryanodine Receptor Channels under Near-physiological Ionic Conditions

Unitary Ca2+ current through cardiac ryanodine receptor channels under quasi-physiological ionic conditions

Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes

Unitary conductance Na+ channel isoforms cardiac NB2a neuroblastoma cells

Unitary construction

Unitary control quantum ensembles - maximizing signal intensity coherent spectroscopy

Unite Conquer

United Kingdom set air quality emission standards

United Kingdom - promises, promises

United Nations conferences, 1970-1995

United States Ocean Commission Declares Oceans Are Trouble

United States Rejoins International Fusion-Research Project

United States backs climate panel findings

United States backs soil strategy fight global warming

United States export subsidies wheat - strategic trade policy expensive beggar-thy-neighbor tactic?

United States priority skills shortage

United States pledges rethink rejection fusion trial

United States greenhouse gas reduction system

United sense. .

Uniting la frontera - ongoing efforts establish transboundary park

Uniting general patterns distribution species

Units determination Stone index requirement scheme estimation

Unity diversity. perspective methods, contributions, future comparative physiology

Univacuolar refractile hemocytes from the tunicate Ciona intestinalis are cytotoxic for mammalian erythrocytes in vitro

Univariate Distribution Analysis to Evaluate Variable Rate Fertilization

Univariate bivariate admixture analyses serum glucose glycated hemoglobin distributions Jerusalem population sample

Universal alignment hydrogen levels semiconductors, insulators solutions

Universal and group-specific real-time PCR diagnosis of flavescence doree (16Sr-V), bois noir (16Sr-XII) and apple proliferation (16Sr-X) phytoplasmas from field-collected plant hosts and insect vectors

Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques

Universal behaviour compressive failure brittle materials

Universal biological scaling and mortality

Universal community carrier screening cystic fibrosis?

Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2

Universal disservice

Universal nodal Fermi velocity

Universal peekaboo

Universal power laws govern intermittent rarity communities interacting species

Universal quantum simulators

Universal scaling relations food webs

Universal signals control slime mold stalk formation

Universal vector?

Universality and flexibility in gene expression from bacteria to human

Universality scaling disordering smectic liquid crystal

Universality classes optimal channel networks

Universality energy electron transfer processes photosystem I

Universality rare fluctuations turbulence critical phenomena

Universality turbulence

Universally conserved translation initiation factors

Universities Promise More Tech Transfer

Universities business fight information

Universities balk OMB funding rules

Universities battle extra funds bid boost quality

Universities chide NIH emergency aid

Universities confront changing markets

Universities gain backing biotech

Universities encourage industrialists roots

Universities face cash shortfall stock-market slide hits charities

Universities face global challenge

Universities feel heat competition

Universities protest Australian spending cuts

Universities puncture modest regulatory experiment balloon

Universities raise game, money doesnt flow

Universities rally cuts Pentagon-funded science

Universities review policies onsite classified science

Universities seek atone Nazi

Universities step challenge

Universities control biomedicine

Universities warned threat links weapons labs

Universities win as Africa reverses 1997 funding trend

Universities, NIH hear price isnt essential drugs

Universities - center U.S. science

University failed acknowledge exoneration

University K-12 Science Outreach Programs - How Can We Reach Broad Audience?

University Life Science Programs Agricultural Biotechnology

University buildings named shaky ground

University cash crisis blocks career paths

University centers ease product progress

University challenge Britain

University company exploit heart data

University confronts rival Lake Tahoe

University consulting - breaking barriers

University cuts lack real justification

University debate boils Australia

University equipment fund meets mixed response

University faces wartime slaves

University funding feels large chill

University funding tied performance

University hospital-based drug information service in a developing country

University libraries put pen paper journal pricing protest

University museum seeks independence

University Cambridge team MIT

University rectors join task force reforms

University reform key improving science

University renames faculty row eugenics advocate

University science touch base NASA

University settles patients trade 'stolen' embryos

University teaching hospitals battle scarce funds Berlin

University-industry partnership

Unjamming traffic computers

Unknown primary carcinoma - Randomised investigations needed identify optimal treatments benefits

Unleashing Force Cladistics? Metazoan Phylogenetics Hypothesis Testing

Unleashing yeast genetics on a factor-independent mechanism of internal translation initiation

Unlicensed information highway

Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system

Unlike mice, dogs exhibit effective glucoregulation low-dose portal peripheral glucose infusion

Unlike quaternary formation transition, tertiary formation change 240s loop allosteric aspartate transcarbamylase requires active site saturation substrate completion

Unlikely havens

Unlimited light

Unlimited mileage telomerase?

Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal models

Unloaded shortening increases peak Ca2+ transients accelerates decay rat single cardiac myocytes

Unloading arterial baroreceptors neurogenic hypertension

Unloading induces transcriptional activation sarco(endo)plasmic reticulum Ca2+-ATPase 1 gene muscle

Unloading-induced remodeling normal hypertrophic left ventricle

Unlocking dislocation secrets

Unlocking family secrets - K+ channel transmembrane domains

Unlocking Molecular Structure Fungal Melanin Using 13C Biosynthetic Labeling Solid-State NMR

Unlocking gates gene expression

Unlocking the mysteries of leaf primordia formation

Unlocking secrets brain

Unlocking secrets brain, part II

Unmasking Ligand Binding Motifs - Identification Chemokine Receptor Motif NMR Investigations Antagonist Peptides

Unmasking Tandem Site Interaction Human Acetylcholinesterase. Substrate Activation Cationic Acetanilide Substrate

Unmasking cheating gene

Unmasking accessory pathway conduction adenosine-induced atrioventricular nodal block radiofrequency catheter ablation

Unmasking black holes

Unmasking electronic energy transfer conjugated polymers suppression O2 quenching

Unmasking mRNA clam oocytes - function phosphorylation 3 UTR masking element-binding protein fertilization

Unmasking accessory pathway ventriculoatrial conduction catecholamines

Unmasking hydrogen tunneling horse liver alcohol dehydrogenase response site-directed mutagenesis

Unmasking sex-ratio biasing targeted examination

Unmasking S-Phase-Promoting Potential Cyclin B1

Unmasking emotional unconscious

Unmasking the functions of the chromaffin cell a7 nicotinic receptor by using short pulses of acetylcholine and selective blockers

Unmasking killer's accomplice

Unmatched tempo of evolution in Southern African semi-desert ice plants

Unmixing Hawaiian cocktails

Unmodified caustics-impregnated carbons control hydrogen sulfide emissions sewage cure plants

Unnatural base pairs for specific transcription

Unnatural disaster

Unnatural selection

Unopposed phosphatase effect initiates ezrin dysfunction. potential mechanism anoxic injury

Unopposed positive selection autoreactivity mice expressing class II MHC thymic cortex

Unorthodox Defense Model Plant

Unpaired Structures SCA10 (ATTCT)n(AGAAT)n Repeats

Unpaired terminal nucleotides and 5' monophosphorylation govern 3' polyadenylation by Escherichia coli poly(A) polymerase I

Unpalatable evolutionary principles

Unpasteurized juice - FDA chances food safety?

Unphysiological effects contributing asparaginase toxicity vitro

Unplanned pregnancies are associated with less likelihood of prolonged breast-feeding among primiparous women in Ghana

Unplanned pregnancy major determinant inadequate prenatal care

Unplugged unbowed

Unpopular Opinions Need Not Apply

Unprecedented gift boosts basic physics Canada

Unprecedented levels genetic variation inbreeding depression island population Black-footed Rock-wallaby

Unpredictability correlated answer selection - linkage initial frequency matter

Unpredictability correlated answer selection - pleiotropy sampling interact

Unpredictable evolution 30-year study Darwin's finches

Unpredictable fitness transitions between haploid and diploid strains of the genetically loaded yeast Saccharomyces cerevisiae

Unpredictable offspring survivorship damselfly, Megaloprepus coerulatus, shapes parental behavior, constrains sexual selection, challenges traditional fitness estimates

Unraveling Monogenic Channelopathies and Their Implications for Complex Polygenic Disease

Unraveling V(D)J Recombination - Insights Gene Regulation

Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element

Unraveling membrane protein

Unraveling a region-specific hyper-recombination phenomenon: genetic control and modalities of terminal recombination in Escherichia coli

Unraveling aircraft impacts

Unraveling bacteria's dependable homing scheme

Unraveling cancer risk cellular molecular tools

Unraveling chemosensory diversity

Unraveling codes

Unraveling selection in the mitochondrial genome of Drosophila

Unraveling the Evolutionary Radiation of the Thoracican Barnacles Using Molecular and Morphological Evidence: A Comparison of Several Divergence Time Estimation Approaches

Unraveling the Function of the Rhodospirillum rubrum Activator of Polyhydroxybutyrate (PHB) Degradation: the Activator Is a PHB-Granule-Bound Protein (Phasin)

Unraveling Mechanisms Involved Motor Neuron Degeneration ALS

Unraveling diabetes

Unraveling the cytoplasmic interactions of the cadherin superfamily

Unraveling the effects of plant hydraulics on stomatal closure during water stress in walnut

Unraveling electronic formation individual photosynthetic pigment-protein complexes

Unraveling the function of glycosyltransferases in Streptococcus thermophilus Sfi6

Unraveling the genetics and mechanisms of cardiac arrhythmia

Unraveling kinetic complexity interprotein electron transfer reactions

Unraveling the mystery of Nod factor signaling by a genomic approach in Medicago trunactula

Unraveling the nanostructure of supramolecular assemblies of hydrogen-bonded rosettes on graphite: an atomic force microscopy study

Unraveling organization internal nuclear matrix - RNA-dependent anchoring NuMA lamin scaffold

Unraveling riddle ProCys tRNA synthetase

Unraveling function aerosols climate change

Unraveling the secrets of Alzheimer's b-amyloid fibrils

Unraveling secrets monarchs

Unraveling signals global climate change

Unraveling substrate-metal binding site ferrochelatase - X-ray uptake spectroscopic study

Unraveling weave spider silk

Unraveling yarn ancon sheep

Unravelling gene interactions

Unravelling Indian rope-trick

Unravelling chemical basis competitive scent marking house mice

Unravelling signal-transduction network B lymphocytes

Unrealistic desiccation marine stratocumulus clouds enhanced solar uptake

Unrecorded naturalized plants Korea

Unreduced pollen hexaploid sweetpotato (Ipomoea batatas)

Unrelated helpers in a social insect

Unreliable standard muscle hydration obesity

Unrepaired heteroduplex DNA in Saccharomyces cerevisiae is decreased in RAD1 RAD52-independent recombination

Unresectable hepatocellular carcinoma in cirrhosis. Survival, prognostic factors, and unexpected side effects after transcatheter arterial chemoembolization

Unresolvable endings - defective telomeres failed separation

Unresolved Problems Condor Recovery Program - Response Risebrough

Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1a, an inhibitor of primitive normal hematopoietic cells

Unresponsiveness cannabinoids reduced addictive effects opiates CB1 receptor knockout mice

Unrestrained 5 ns molecular dynamics simulation cisplatin-DNA 1,2-GG adduct rationale NMR features reveals increased conformational flexibility platinum binding site

Unrestricted free access works continue

Unruly sun emerges solar observatory's preliminary results

Unruptured intracranial aneurysms elderly patients

Unsafe boating

Unsaponifiable lipid biosynthesis seedling Euphorbia lathyris L.. bypass alcoholic fermentation

Unsatisfactory results recurrences surgery carpal tunnel syndrome. Report 185 reoperations

Unsaturated fat energy intake stimulate increment energy intake ameliorates fatty liver extended alcohol consumption rats

Unsaturated fatty acid content seston tropho-dynamic coupling lakes

Unsaturated fatty acids active molecules glucan-synthase-inhibitory fraction extracted entomophthoralean protoplasts

Unsaturated fatty acids associated with glycogen may inhibit glucose-6 phosphatase in rat liver

Unsaturated fatty acids in membrane lipids protect the photosynthetic machinery against salt-induced damage in Synechococcus

Unsaturated fatty acids incorporated HDL hypo- hyperalphalipoproteinemia: relationship HDL-cholesterol degree

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR

Unsaturated fatty acids regulate gene expression cellular retinol-binding protein, type II rat jejunum

Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells

Unsaturated fish communities African rivers

Unsaturated phospholipid acyl chains required constitute membrane binding sites factor VIII

Unsaturation of the membrane lipids of chloroplasts stabilizes the photosynthetic machinery against low-temperature photoinhibition in transgenic tobacco plants

Unscrambling disabled brain

Unscrambling color vision

Unscrambling time fossil record

Unseasonal Snowflakes

Unseemly competition

Unseen forces - effect bacteria animal progress

Unsegmented Annelids? Possible Origins Four Lophotrochozoan Worm Taxa

Unsettled air

Unsolved problems noise

Unsound reasoning

Unspecific aortoarteritis involvement pulmonary arteries

Unspecific hydrophobic stabilization of folding transition states

Unspinning web

Unstable design

Unstable diabetic condition produced dose streptozotocin rats

Unstable evolutionarily stable strategy oscillation. model lateral asymmetry scale-eating cichlids

Unstable heart rate temperature regulation predict mortality AKR/J mice

Unstable models incorrect forms

Unstable molecules form stable tissues

Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

Unstable radii muscular blood vessels

Unstable social formation population crash Tasmanian native hen, Tribonyx mortierii

Unstable water flow in a layered soil: I. Effects of a stable water-repellent layer

Unstable water flow in a layered soil: II. Effects of an unstable water-repellent layer

Unstable white flower color groundnut (Arachis hypogaea L.)

Unsteady aerodynamic force generation by a model fruit fly wing in flapping motion

Unsteady aerodynamic forces of a flapping wing

Unsteady aerodynamics

Unsteady forces and flows in low Reynolds number hovering flight: two-dimensional computations vs robotic wing experiments

Unsteady mechanisms force generation aquatic aerial locomotion

Unsteady similarity solutions oscillating ocean gyres

Unsteady-state gas exchange storage diving marine mammals - harbor porpoise gray seal

Unstoppable force

Unstructured Individual Variation Demographic Stochasticity

Unsung Perennials

Unsuspected diversity marine aerobic anoxygenic phototrophs

Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development

Untangling Checkpoints

Untangling latitudinal richness gradients higher taxonomic levels - familial perspectives diversity Novel World bat communities

Untangling multiple factors spatial distributions - lilies, gophers, rocks

Untangling Phylogeny Neotropical Lianas (Bignonieae, Bignoniaceae)

Untangling Roots Cancer

Untangling the wires: a strategy to trace functional interactions in signaling and gene networks

Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa

Untenured Toronto

Untethered satellite produced data

Untimely Fall Harvest Affects Dry Matter Yield and Root Organic Reserves in Field-Grown Alfalfa

Untutored song, reproductive success song learning

Untying Lancastrian bundle - valuing ecosystems eco-system services wetland mitigation

Untying the Gordian knot of cytokinesis: role of small G proteins and their regulators

Unusual 1H NMR chemical shifts support (His) Ce1(single bond)H O(double bond)C H-bond - proposal reaction-driven ring flip mechanism serine protease catalysis

Unusual Benefits Macromolecular Shielding Polyethylene Glycol Reactions Diffusional Limit - The Case Factor VIIai Tissue Factor

Unusual Ca2+-Calmodulin Binding Interactions Microtubule-Associated Protein F-STOP

Unusual Integrase Gene Expression on the clc Genomic Island in Pseudomonas sp. Strain B13

Unusual Life Style Giant Chlorella Viruses

Unusual NMR, EPR, Mossbauer properties Chromatium vinosum 2(4Fe-4S) ferredoxin

Unusual Plasmodium malariae-like parasites ineast Asia

Unusual Rel-like architecture DNA-binding domain transcription factor NFATc

Unusual Sources

Unusual affinity cyanide ferrous ferric Scapharca inaequivalvis homodimeric hemoglobin. Equilibria kinetics response

Unusual analyte adsorption effects inert LC components

Unusual ancestry of dehydratases associated with quinate catabolism in Acinetobacter calcoaceticus

Unusual arrangement hsp68 locus virilis species group Drosophila implicates evolutionary loss hsp68 gene

Unusual bacterioplankton community formation ultra-oligotrophic Crater Lake

Unusual behaviour gamma- delta-lactones dichloromethylenation tris(dimethylamino)phosphine-tetrachloromethane

Unusual binding mode HIV-1 protease inhibitor explains potency multi-drug-resistant virus strains

Unusual binding stoichiometries cooperativity observed binary ternary complex structure single active pore R67 dihydrofolate reductase D2 symmetric protein

Unusual capture Batocera lineolata Paris region (Col. Cerambycidae)

Unusual carotenoid composition and a new type of xanthophyll cycle in plants

Unusual case of hypertonic hemorrhage

Unusual obstructive renal failure - Crystalluria stimulated amoxicillin

Unusual cells treat Parkinson's disease

Unusual charge configurations in transcription factors of the basic RNA polymerase II initiation complex

Unusual choanal polyps

Unusual compact rDNA gene arrangements members Ascomycota - proof molecular co-evolution ITS1 ITS2

Unusual complications intermittent self-catheterisation spinal cord injury patients

Unusual degradation a-b complexes Xenopus oocytes b-subunits Xenopus gastric H-K-ATPase

Unusual dynamics of extinction in a simple ecological model

Unusual influence myo-inositol phospholipid biosynthesis Cryptococcus neoformans

Unusual effects engineered disulfide global local protein stability

Unusual electrophoretic patterns phosphoglucomutase fumarase population Lecithochirium rufoviride (Trematoda - Hemiuridae) parasite Conger conger

Unusual electrostatic effects binding C1q anionic liposomes - function anionic phospholipid domains line tension

Unusual enzymes involved in five pathways of glutamate fermentation

Unusual eosinophilia not detected by an automated haematological analyser in a patient with liver cirrhosis

Unusual fatty acid compositions of the hyperthermophilic archaeon Pyrococcus furiosus and the bacterium Thermotoga maritima

Unusual features of the Drosophila melanogaster telomere transposable element HeT-A are conserved in Drosophila yakuba telomere elements

Unusual filamentous virus-like particles symptomless blackberry severe leaf curling virus indicator Rubus macraei, anomalous data degenerate badnav