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Research > Chapter 18020



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Mutations in the -10 TATAAT sequence of the gyrA promoter affect both promoter strength and sensitivity to DNA supercoiling

Mutations in the 1,25-dihydroxyvitamin D3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with basal transcription factor IIB, in vitro

Mutations 1.1 subdomain Escherichia coli sigma factor s70 disruption formation

Mutations in the 2C Region of Poliovirus Responsible for Altered Sensitivity to Benzimidazole Derivatives

Mutations in the 3b-Hydroxysterol 24-Reductase Gene Cause Desmosterolosis, an Autosomal Recessive Disorder of Cholesterol Biosynthesis

Mutations in the 5' End of the Human Immunodeficiency Virus Type 1 Polypurine Tract Affect RNase H Cleavage Specificity and Virus Titer

Mutations in the 7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome

Mutations in the 8 kDa dynein light chain gene disrupt sensory axon projections in the Drosophila imaginal CNS

Mutations in the AHI1 Gene, Encoding Jouberin, Cause Joubert Syndrome with Cortical Polymicrogyria

Mutations in the ATP-binding domain of Escherichia coli rho factor affect transcription termination in vivo

Mutations in the Anopheles gambiae Pink-Eye and White genes define distinct, tightly linked eye-color loci

Mutations in the Arabidopsis Phosphoinositide Phosphatase Gene SAC9 Lead to Overaccumulation of PtdIns(4,5)P2 and Constitutive Expression of the Stress-Response Pathway

Mutations in the B2 bradykinin receptor reveal a different pattern of contacts for peptide agonists and peptidic antagonists

Mutations in the BRWD3 Gene Cause X-Linked Mental Retardation Associated with Macrocephaly

Mutations in the C-Terminal Region of TraM Provide Evidence for In Vivo TraM-TraD Interactions during F-Plasmid Conjugation

Mutations in the C-terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro

Mutations CDP-choline pathway phospholipid biosynthesis bypass demand essential phospholipid transfer protein

Mutations in the CEP290 (NPHP6) Gene Are a Frequent Cause of Leber Congenital Amaurosis

Mutations CYP51 gene correlated sensitivity sterol 14a-demethylation inhibitors field isolates Mycosphaerella graminicola

Mutations in the Caenorhabditis elegans b-tubulin gene mec-7: effects on microtubule assembly and stability and on tubulin autoregulation

Mutations in the Central Cavity and Periplasmic Domain Affect Efflux Activity of the Resistance-Nodulation-Division Pump EmhB from Pseudomonas fluorescens cLP6a

Mutations in the Central Domain of Potato Virus X TGBp2 Eliminate Granular Vesicles and Virus Cell-to-Cell Trafficking

Mutations in the Cytoplasmic Domain of a Paramyxovirus Fusion Glycoprotein Rescue Syncytium Formation and Eliminate the Hemagglutinin-Neuraminidase Protein Requirement for Membrane Fusion

Mutations in the D strand of the human CD4 V1 domain affect CD4 interactions with the human immunodeficiency virus envelope glycoprotein gp120 and HLA class II antigens similarly

Mutations in the D-2-Hydroxyglutarate Dehydrogenase Gene Cause D-2-Hydroxyglutaric Aciduria

Mutations in the DNA gyrB gene that are temperature sensitive for lambda site-specific recombination, Mu growth, and plasmid maintenance

Mutations DNA ligase I gene individual immunodeficiencies cellular hypersensitivity DNA-damaging agents

Mutations in the DNA-binding Domain of the Transcription Factor Bright Act as Dominant Negative Proteins and Interfere with Immunoglobulin Transactivation

Mutations in the Dictyostelium heterotrimeric G protein a subunit a5 alter the kinetics of tip morphogenesis

Mutations in the Dimerization Domain of the b Subunit from the Escherichia coli ATP synthase. Deletions Disrupt Function but not Enzyme Assembly

Mutations in the DnaA binding sites of the replication origin of Escherichia coli

Mutations in the Drosophila Condensin Subunit dCAP-G: Defining the Role of Condensin for Chromosome Condensation in Mitosis and Gene Expression in Interphase

Mutations in the Drosophila Orthologs of the F-Actin Capping Protein a- and b-Subunits Cause Actin Accumulation and Subsequent Retinal Degeneration

Mutations Drosophila aPS2 integrin subunit uncover features adhesion site assembly

Mutations in the Effector Binding Loops in the C2A and C2B Domains of Synaptotagmin I Disrupt Exocytosis in a Nonadditive Manner

Mutations in the Embryonal Subunit of the Acetylcholine Receptor (CHRNG) Cause Lethal and Escobar Variants of Multiple Pterygium Syndrome

Mutations in the Endodomain of Sindbis Virus Glycoprotein E2 Define Sequences Critical for Virus Assembly

Mutations in the Escherichia coli UvrB ATPase motif compromise excision repair capacity

Mutations in the Escherichia coli dnaG gene suggest coupling between DNA replication and chromosome partitioning

Mutations in the Escherichia coli fnr and tgt genes: control of molybdate reductase activity and the cytochrome d complex by fnr

Mutations in the Estrogen Receptor DNA-binding Domain Discriminate between the Classical Mechanism of Action and Cross-talk with Stat5b and Activating Protein 1 (AP-1)

Mutations Exo III motif herpes simplex virus DNA polymerase gene confer altered drug sensitivities

Mutations in the Extracellular Amino-terminal Domain of the NK2 Neurokinin Receptor Abolish cAMP Signaling but Preserve Intracellular Calcium Responses

Mutations Extracellular Domain Membrane-Spanning Domains Interfere Nicotinic Acetylcholine Receptor Maturation

Mutations in the FAD Binding Domain Cause Stress-induced Misoxidation of the Endoplasmic Reticulum Oxidoreductase Erol 1b

Mutations in the FTSJ1 Gene Coding for a Novel S-Adenosylmethionine-Binding Protein Cause Nonsyndromic X-Linked Mental Retardation

Mutations in the GTP-binding site of Gsa alter stimulation of adenylyl cyclase

Mutations in the Gal83 Glycogen-Binding Domain Activate the Snf1/Gal83 Kinase Pathway by a Glycogen-Independent Mechanism

Mutations in the Gene Encoding 3-Hydroxyisobutyryl-CoA Hydrolase Results in Progressive Infantile Neurodegeneration

Mutations in the Gene Encoding Peroxisomal Sterol Carrier Protein X (SCPx) Cause Leukencephalopathy with Dystonia and Motor Neuropathy

Mutations in the Gene Encoding the Sigma 2 Subunit of the Adaptor Protein 1 Complex, AP1S2, Cause X-Linked Mental Retardation

Mutations in the Gene Encoding the Wnt-Signaling Component R-Spondin 4 (RSPO4) Cause Autosomal Recessive Anonychia

Mutations in the Gene KCNV2 Encoding a Voltage-Gated Potassium Channel Subunit Cause Cone Dystrophy with Supernormal Rod Electroretinogram in Humans

Mutations in the HYDRA1 gene of Arabidopsis perturb cell shape and disrupt embryonic and seedling morphogenesis

Mutations in the Human Cytomegalovirus UL27 Gene That Confer Resistance to Maribavir

Mutations in the JARID1C Gene, Which Is Involved in Transcriptional Regulation and Chromatin Remodeling, Cause X-Linked Mental Retardation

Mutations in the Jun Delta region suggest an inverse correlation between transformation and transcriptional activation

Mutations in the K+/Cl- Cotransporter Gene kazachoc (kcc) Increase Seizure Susceptibility in Drosophila

Mutations in the KIAA0196 Gene at the SPG8 Locus Cause Hereditary Spastic Paraplegia

Mutations in the Kvb2 binding site for NADPH and their effects on Kv1.4

Mutations MHC class II binding domains staphylococcal enterotoxin A differentially affect T cell receptor Vb specificity

Mutations MotA protein Escherichia coli reveal domains critical proton conduction

Mutations in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs Alter Functional Interactions with the Entry/Fusion Receptors HVEM, Nectin-2, and 3-O-Sulfated Heparan Sulfate but Not with Nectin-1

Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions

Mutations in the N-Terminal Region of Influenza Virus PB2 Protein Affect Virus RNA Replication but Not Transcription

Mutations in the NH2-terminal domain of the signal peptide of preproparathyroid hormone inhibit translocation without affecting interaction with signal recognition particle

Mutations in the NS1 Protein of Swine Influenza Virus Impair Anti-Interferon Activity and Confer Attenuation in Pigs

Mutations in the NTP-binding motif to minute virus of mice (MVM) NS-1 protein uncouple ATPase and DNA helicase functions

Mutations in the Novel Mitochondrial Protein REEP1 Cause Hereditary Spastic Paraplegia Type 31

Mutations in the Nucleosome Core Enhance Transcriptional Silencing

Mutations in the P1 promoter region of Micromonospora echinospora

Mutations in the PPPY motif of vesicular stomatitis virus matrix protein reduce virus binding by inhibiting a late step in virion release

Mutations in the Pho2 (Bas2) Transcription Factor That Differentially Affect Activation with Its Partner Proteins Bas1, Pho4, and Swi5

Mutations in the Putative HR-C Region of the Measles Virus F2 Glycoprotein Modulate Syncytium Formation

Mutations Putative Pore-Forming Segment Favor Short-Lived Wild-Type Kir2.1 Pore Conformations

Mutations in the Putative Zinc-Binding Motif of UL52 Demonstrate a Complex Interdependence between the UL5 and UL52 Subunits of the Human Herpes Simplex Virus Type 1 Helicase/Primase Complex

Mutations in the R2 Subunit of Ribonucleotide Reductase That Confer Resistance to Hydroxyurea

Mutations in the RING Domain of TFB3, a Subunit of Yeast Transcription Factor IIH, Reveal a Role in Cell Cycle Progression

Mutations in the RNA Polymerase III Subunit Rpc11p That Decrease RNA 3 Cleavage Activity Increase 3-Terminal Oligo(U) Length and La-Dependent tRNA Processing

Mutations in the RNase H Primer Grip Domain of Murine Leukemia Virus Reverse Transcriptase Decrease Efficiency and Accuracy of Plus-Strand DNA Transfer

Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function

Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity

Mutations in the SF1-U2AF59-U2AF23 Complex Cause Exon Skipping in Schizosaccharomyces pombe

Mutations in the Saccharomyces cerevisiae LSM1 Gene That Affect mRNA Decapping and 3 End Protection

Mutations in the Saccharomyces cerevisiae RPB1 Gene Conferring Hypersensitivity to 6-Azauracil

Mutations in the Slow Skeletal Muscle Fiber Myosin Heavy Chain Gene (MYH7) Cause Laing Early-Onset Distal Myopathy (MPD1)

Mutations in the Stalk of the Measles Virus Hemagglutinin Protein Decrease Fusion but Do Not Interfere with Virus-Specific Interaction with the Homologous Fusion Protein

Mutations in the Substrate Binding Site of Thrombin-activatable Fibrinolysis Inhibitor (TAFI) Alter Its Substrate Specificity

Mutations in the Tat gene are responsible for human immunodeficiency virus type 1 postintegration latency in the U1 cell line

Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement

Mutations in the Translated Region of the Lactase Gene (LCT) Underlie Congenital Lactase Deficiency

Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor

Mutations in the U5 Sequences Adjacent to the Primer Binding Site Do Not Affect tRNA Cleavage by Rous Sarcoma Virus RNase H but Do Cause Aberrant Integrations In Vivo

Mutations in the Ubiquitin Binding UBZ Motif of DNA Polymerase H Do Not Impair Its Function in Translesion Synthesis during Replication

Mutations in the Vaccinia Virus A33R and B5R Envelope Proteins That Enhance Release of Extracellular Virions and Eliminate Formation of Actin-Containing Microvilli without Preventing Tyrosine Phosphorylation of the A36R Protein

Mutations in the X-Linked Cyclin-Dependent Kinase-Like 5 (CDKL5/STK9) Gene Are Associated with Severe Neurodevelopmental Retardation

Mutations in the X-linked E1a subunit of pyruvate dehydrogenase exon: skipping, insertion of duplicate sequence, and missense mutations leading to the deficiency of the pyruvate dehydrogenase complex

Mutations in the Yeast MRF1 Gene Encoding Mitochondrial Release Factor Inhibit Translation on Mitochondrial Ribosomes

Mutations in the Yersinia pseudotuberculosis Type III Secretion System Needle Protein, YscF, That Specifically Abrogate Effector Translocation into Host Cells

Mutations in the a subunit of eukaryotic translation initiation factor 2 (eIF-2a) that overcome the inhibitory effect of eIF-2a phosphorylation on translation initiation

Mutations in the a-amanitin conserved domain of the largest subunit of yeast RNA polymerase III affect pausing, RNA cleavage and transcriptional transitions

Mutations in the a1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans

Mutations in the a2(IV) basement membrane collagen gene of Caenorhabditis elegans produce phenotypes of differing severities

Mutations in the a8 Loop of Human APE1 Alter Binding and Cleavage of DNA Containing an Abasic Site

Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity

Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for b-lactam antibiotics

Mutations in the araC regulatory gene of Escherichia coli B/r that affect repressor and activator functions of AraC protein

Mutations in the arylsulfatase A pseudodeficiency allele causing metachromatic leukodystrophy

Mutations in the aspartate receptor of Escherichia coli which affect aspartate binding

Mutations in the autoinhibitor site of the regulatory subunit of cAMP-dependent protein kinase I. Replacement of Ala-97 and Ser-99 interferes with reassociation with the catalytic subunit

Mutations in the b-subunit Thr159 and Glu184 of the Rhodospirillum rubrum F0F1 ATP synthase reveal differences in ligands for the coupled Mg2+- and decoupled Ca2+-dependent F0F1 activities

Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity

Mutations in the bglY gene increase the frequency of spontaneous deletions in Escherichia coli K-12

Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis

Mutations in the bli-4 (I) locus of Caenorhabditis elegans disrupt both adult cuticle and early larval development

Mutations in the carboxyl-terminal domain of phospholipase C-b1 delineate the dimer interface and a potential Gaq interaction site

Mutations in the carboxyl-terminal domain of the small-hepatitis B virus envelope protein impair the assembly of hepatitis delta virus particles

Mutations in the carboxyl-terminal propeptide of the Proa1(I) chain of type I collagen result in defective chain association and produce lethal osteogenesis imperfecta

Mutations cardiac troponin I gene hypertrophic cardiomyopathy

Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity

Mutations in the catalytic subunit of the cAMP-dependent protein kinase interfere with holoenzyme formation without disrupting inhibition by protein kinase inhibitor

Mutations in the cdc10 start gene of Schizosaccharomyces pombe implicate the region of homology between cdc10 and SW16 as important for p85cdc10 function

Mutations the polypurine tract HIV-1 finding delayed replication

Mutations chloride channel gene, CLCNKB, Bartter's syndrome type III

Mutations in the connection domain of HIV-1 reverse transcriptase increase 3-azido-3-deoxythymidine resistance

Mutations in the conserved proline 43 residue of the uncE protein (subunit c) of Escherichia coli F1F0-ATPase alter the coupling of F1 to F0

Mutations in the cytoplasmic domain of the integrin b1 chain indicate a role for endocytosis factors in bacterial internalization

Mutations in the double-stranded RNA-activated protein kinase insert region that uncouple catalysis from eIF2a binding

Mutations in the elongation factor 2 gene which confer resistance to diphtheria toxin and Pseudomonas exotoxin A. Genetic and biochemical analyses

Mutations in the extra sex combs and Enhancer of Polycomb Genes Increase Homologous Recombination in Somatic Cells of Drosophila melanogaster

Mutations gene encoding 3b-hydroxysteroid-D8-D7-isomerase X-linked dominant Conradi-Hunermann syndrome

Mutations gene encoding e-sarcoglycan myoclonus-dystonia syndrome

Mutations gene encoding gap junction protein b-3 autosomal dominant hearing impairment

Mutations gene encoding immunoglobulin m-binding protein 2 spinal muscular atrophy respiratory distress type 1

Mutations in the gene encoding retinol binding protein and retinol deficiency: is there compensation by retinyl esters and retinoic acid?

Mutations gene encoding 3-5 DNA exonuclease TREX1 Aicardi-Goutieres syndrome AGS1 locus

Mutations gene encoding lamin B receptor produce altered nuclear morphology granulocytes (Pelger-Huet anomaly)

Mutations gene encoding latency-associated peptide TGF-b1 Camurati-Engelmann disease

Mutations gene-encoding SERCA1, fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, Brody disease

Mutations in the glnG gene of Escherichia coli that result in increased activity of nitrogen regulator I

Mutations hair cortex keratin hHb6 inherited hair disease monilethrix

Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17b-estradiol-induced androgen receptor transactivation

Mutations heparin-binding domains human basic fibroblast growth factor alter biological activity

Mutations herpes simplex virus major DNA-binding protein gene leading altered sensitivity DNA polymerase inhibitors

Mutations homeodomain humans SIX3 gene holoprosencephaly

Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency

Mutations in the human Ca2+-sensing-receptor gene that cause familial hypocalciuric hypercalcemia

Mutations human Sonic Hedgehog gene holoprosencephaly

Mutations human a-tectorin gene autosomal dominant non-syndromic hearing impairment

Mutations in the hydrophobic surface of an amphipathic groove of 14-3-3x disrupt its interaction with Raf-1 kinase

Mutations integrin a7 gene congenital myopathy

Mutations inverted repeats Tn3 affect binding transposase transposition immunity

Mutations in the lac P2 promoter

Mutations in the leader sequence and initiation codon of the gene for ribosomal protein S20 (rpsT) affect both translational efficiency and autoregulation

Mutations in the listerial proB gene leading to proline overproduction: effects on salt tolerance and murine infection

Mutations in the lysosomal b-galactosidase gene that cause the adult form of GMI gangliosidosis

Mutations in the met Oncogene Unveil a Dual Switch Mechanism Controlling Tyrosine Kinase Activity

Mutations in the mitochondrial split gene COXI are preferentially located in exons: a mapping study of 170 mutants

Mutations in the mutY gene of Escherichia coli enhance the frequency of targeted G:C- >T:A transversions induced by a single 8-oxoguanine residue in single-stranded DNA

Mutations in the novel membrane protein Spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster

Mutations nsP1 coding sequence Sindbis virus restrict viral replication secondary cultures chick embryo fibroblasts prepared aged primary culture

Mutations in the nucleotide binding domain 1 signature motif region rescue processing and functional defects of cystic fibrosis transmembrane conductance regulator DF508

Mutations plakophilin 1 gene finding ectodermal dysplasia/skin fragility syndrome

Mutations poliovirus 3CD proteinase S1-specificity pocket affect substrate recognition RNA binding

Mutations in the pore regions of yeast K+ channel YKC1 affect gating by extracellular K+

Mutations in the precursor region of a Bacillus subtilis sporulation sigma factor

Mutations in the protein phosphatase 1 gene at 87/B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster

Mutations in the recD gene of Escherichia coli that raise the copy number of certain plasmids

Mutations in the rpoH (htpR) gene of Escherichia coli K-12 phenotypically suppress a temperature-sensitive mutant defective in the s70 subunit of RNA polymerase

Mutations skeletal muscle a-actin gene patients actin myopathy nemaline myopathy

Mutations in the small subunit of cyanobacterial ribulose-bisphosphate carboxylase/oxygenase that modulate interactions with large subunits

Mutations in the spoT gene of Salmonella typhimurium: effects on his operon expression

Mutations in the structural genes for eukaryotic initiation factors 2a and 2b of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA

Mutations testis/liver isoform phosphorylase kinase subunit (PHKG2) autosomal liver glycogenosis gsd rat humans

Mutations in the third a-helix of bovine growth hormone dramatically affect its intracellular distribution in vitro and growth enhancement in transgenic mice

Mutations third, preliminary second, hypervariable regions DR(b1*0101) eliminate DR1-restricted recognition pertussis toxin peptide

Mutations in the trfA replication gene of the broad-host-range plasmid RK2 result in elevated plasmid copy numbers

Mutations in the v-Rel Transactivation Domain Indicate Altered Phosphorylation and Identify a Subset of NF-kB-Regulated Cell Death Inhibitors Important for v-Rel Transforming Activity

Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides

Mutations in the yeast KEX2 gene cause a Vma- like phenotype: a possible role for the Kex2 endoprotease in vacuolar acidification

Mutations in the yeast proteasome b-type subunit pre3 uncover position-dependent effects of proteasomal peptidase activity and in vivo function

Mutations in the yeast vacuolar ATPase result in the mislocalization of vacuolar proteins

Mutations in the zinc-binding motif of the reovirus capsid protein s3 eliminate its ability to associate with capsid protein m1

Mutations in trans that affect formate dehydrogenase (fdhF) gene expression in Salmonella typhimurium

Mutations transcriptional regulator ATRX establish functional significance PHD-like domain

Mutations adjascent genes epidermodysplasia verruciformis

Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein s1

Mutations type I procollagen genes osteogenesis imperfecta

Mutations in uvrD induce the SOS response in Escherichia coli

Mutations v-myb alter differentiation myelomonocytic cells transformed oncogene

Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain

Mutations yeast U5 snRNA alter specificity 5 splice-site cleavage

Mutations induced by methylene blue plus light in single-stranded M13mp2

Mutations introduced along the HTLV-I envelope gene result in a non-functional protein: a basis for envelope conservation?

Mutations leading to constitutive expression from the TOL plasmid meta-cleavage pathway operon are located at the C-terminal end of the positive regulator protein XylS

Mutations occur in the Ig Sm region but rarely in Sc regions prior to class switch recombination

Mutations of Arg440 and Gly455/Gly456 Oppositely Change pH Sensing of Na+/H+ Exchanger 1

Mutations of Bacterial RNA Polymerase Leading to Resistance to Microcin J25

Mutations of Bacteriophage T4 59 Helicase Loader Defective in Binding Fork DNA and in Interactions with T4 32 Single-stranded DNA-binding Protein

Mutations of CDKL5 Cause a Severe Neurodevelopmental Disorder with Infantile Spasms and Mental Retardation

Mutations of Epstein-Barr Virus gH That Are Differentially Able To Support Fusion with B Cells or Epithelial Cells

Mutations of Gsa designed to alter the reactivity of the protein with bacterial toxins. Substitutions at Arg187 result in loss of GTPase activity

Mutations of Hydrophobic Residues in the N-terminal Domain of Troponin C Affect Calcium Binding and Exchange with the Troponin C-Troponin I96-148 Complex and Muscle Force Production

Mutations PKD1 ADPKD2 cysts recommend pathogenic influence trans-heterozygous mutations

Mutations of Presenilin Genes in Dilated Cardiomyopathy and Heart Failure

Mutations SCN1A, encoding neuronal sodium channel, families GEFS+2

Mutations of Tubulin Glycylation Sites Reveal Cross-talk between the C Termini of a- and b-Tubulin and Affect the Ciliary Matrix in Tetrahymena

Mutations of a Drosophila NPC1 Gene Confer Sterol and Ecdysone Metabolic Defects

Mutations of a Redundant a-Tubulin Gene Affect Caenorhabditis elegans Early Embryonic Cleavage via MEI-1/Katanin-Dependent and -Independent Pathways

Mutations conserved residue HIV-1 ribonuclease H affect exo- endonuclease activities

Mutations of an active site threonyl residue promote b elimination and other side reactions of the enediol intermediate of the ribulosebisphosphate carboxylase reaction

Mutations aspartate 103 Hm2 receptor alterations receptor binding properties muscarinic agonists

Mutations of barley b-amylase that improve substrate-binding affinity and thermostability

Mutations of either or both Cys876 and Cys888 residues of sarcoplasmic reticulum Ca2+-ATPase results in a complete loss of Ca2+ transport without a loss of Ca2+-dependent ATPase activity. Role of the Cys876-Cys888 disulfide bond

Mutations of glutamate-84 at the putative potassium-binding site affect camphor binding and oxidation by cytochrome p450cam

Mutations of human myristoyl-CoA: protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae

Mutations immunoglobulin transmembrane cytoplasmic domains - effects intracellular signaling antigen presentation

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates

Mutations phosphorylation sites lamin A prevents nuclear lamina disassembly mitosis

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local b-structure

Mutations of the Act Promoter in Myxococcus xanthus

Mutations of the Corynebacterium glutamicum NCgl1221 Gene, Encoding a Mechanosensitive Channel Homolog, Induce L-Glutamic Acid Production

Mutations of the Gs a-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis

Mutations of the Membrane-Bound Disulfide Reductase DsbD That Block Electron Transfer Steps from Cytoplasm to Periplasm in Escherichia coli

Mutations of the Mitochondrial Holocytochrome c-Type Synthase in X-Linked Dominant Microphthalmia with Linear Skin Defects Syndrome

Mutations of the Quorum Sensing-Dependent Regulator VjbR Lead to Drastic Surface Modifications in Brucella melitensis

Mutations of the Rous sarcoma virus env gene that affect the transport and subcellular location of the glycoprotein products

Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in xenopus oocytes

Mutations of the SAM domain of STE50 differentially influence the MAPK-mediated pathways for mating, filamentous growth and osmotolerance in Saccharomyces cerevisiae

Mutations of the Yku80 C Terminus and Xrs2 FHA Domain Specifically Block Yeast Nonhomologous End Joining

Mutations of the a2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling

Mutations of the b subunit of RNA polymerase alter both transcription pausing and transcription termination in the trp operon leader region in vitro

Mutations b-tubulin gene diverse phenotypes benzimidazole resistance cereal eyespot fungi Tapesia yallundae Tapesia acuformis

Mutations bN102 Residue HbA Not Only Inhibit Ligand-Linked T Re State Transition, Also Profoundly Affect Properties T State Itself

Mutations down-regulated adenoma (DRA) gene congenital chloride diarrhoea

Mutations gene encoding protein kinase A type I-a regulatory subunit patients Carney complex

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus

Mutations mouse H chain prevent polymer assembly

Mutations of the phage l nutL region that prevent the action of Nun, a site-specific transcription termination factor

Mutations of the type A domain of complement factor B that promote high-affinity C3b-binding

Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2'-fluoro-5-methyl-b- L-arabinofuranosyluracil

Mutations of tyrosine 82 in bovine adrenodoxin that affect binding to cytochromes P45011A1 and P45011B1 but not electron transfer

Mutations of vaccinia virus DNA topoisomerase I that stabilized the cleavage complex

Mutations Aromatic Residues Active Site To Alter Selectivity Sulfolobus solfataricus Maltooligosyltrehalose Synthase

Mutations probe formation role G-protein chains

Mutations replacing the leucine codons or altering the length of the amino acid-coding portion of the ilvGMEDA leader region of Escherichia coli

Mutations specifically affecting ligand interaction of the Trg chemosensory transducer

Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-a alter its response to estradiol and 4-hydroxytamoxifen

Mutations that Cause Osteoglophonic Dysplasia Define Novel Roles for FGFR1 in Bone Elongation

Mutations that affect Tn5 insertion into pBR322: importance of local DNA supercoiling

Mutations that affect control of the methylesterase activity of CheB, a component of the chemotaxis adaptation system in Escherichia coli

Mutations that affect the efficiency of translation of mRNA for the cII gene of coliphage lambda

Mutations that affect the folding of ribose-binding protein selected as suppressors of a defect in export in Escherichia coli

Mutations affect regulation phs Salmonella typhimurium

Mutations that affect transcription and cyclic AMP-CRP regulation of the adenylate cyclase gene cya of Salmonella typhimurium

Mutations that affect utilization of a promoter in stationary-phase Bacillus subtilis

Mutations that alter the charge of type I regulatory subunit and modify activation properties of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells

Mutations that alter the primary structure of type I collagen. The perils of a system for generating large structures by the principle of nucleated growth

Mutations alter primary formation type I procollagen long-range effects cleavage procollagen N-proteinase

Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli

Mutations that alters the higher-order structure of its 5' untranslated region affect the stability of chloroplast rps7 mRNA

Mutations that are synthetically lethal with a gas1 allele cause defects in the cell wall of Saccharomyces cerevisiae

Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein

Mutations that change the position of the putative c-phosphate linker in the nucleotide binding domains of CFTR alter channel gating

Mutations confer resistance mycophenolic acid ribavirin sindbis virus map nonstructural protein nsP1

Mutations that convert the four leucine codons of the Salmonella typhimurium leu leader to four threonine codons

Mutations that create new promoters suppress the s54 dependence of glnA transcription in Escherichia coli

Mutations that define the promoter of ompF, a gene specifying a major outer membrane porin protein

Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains

Mutations eliminate demand vertex protein bacteriophage T4 capsid assembly

Mutations that encode partially functional b2 tubulin subunits have different effects on structurally different microtubule arrays

Mutations that improve export of maltose-binding protein in SecB- cells of Escherichia coli

Mutations that improve the ant promoter of Salmonella phage P22

Mutations that improve the binding of yeast FLP recombinase to its substrate

Mutations that improve the pRE promoter of coliphage lambda

Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells

Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the lutropin/choriogonadotropin receptor

Mutations that prevent cyclic nucleotide binding to binding sites A or B of type I cyclic AMP-dependent protein kinase

Mutations that simultaneously alter both sugar and cation specificity in the melibiose carrier of Escherichia coli

Mutations stabilize folding intermediates phage P22 tailspike protein - folding vivo vitro, stability, structural context

Mutations that substitute serine for glycine a1-598 and glycine a1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks

Mutations that uncouple the b-adrenergic receptor from Gs and increase agonist affinity

Mutations nitrofurantoin nitrofurazone resistance Escherichia coli K12

Mutations uncouple human fibroblast growth factor (FGF)-7 biological activity and receptor binding and support broad specificity in the secondary response binding site of FGFs

Mutations which impede loop/sheet polymerization enhance the secretion of human a1-antitrypsin deficiency variants

Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans

Mutations within Helix I of Twist1 Result in Distinct Limb Defects and Variation of DNA Binding Affinities

Mutations within an Intramembrane Leucine Heptad Repeat Disrupt Oligomer Formation of the Rat GABA Transporter 1

Mutations within the ADP (E3-11.6K) Protein Alter Processing and Localization of ADP and the Kinetics of Cell Lysis of Adenovirus-Infected Cells

Mutations C-Terminus Subunit Photosynthetic F1-ATPase Activate MgATP Hydrolysis Attenuate Stimulatory Oxyanion Influence

Mutations within the NH2-terminal transmembrane domain of membrane immunoglobulin (Ig) M alters Iga and Igb association and signal transduction

Mutations within the P2 Domain of Norovirus Capsid Affect Binding to Human Histo-Blood Group Antigens: Evidence for a Binding Pocket

Mutations within the Programmed Cell Death 10 Gene Cause Cerebral Cavernous Malformations

Mutations within the hMLH1 and hPMS2 subunits of the human MutLa mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSa

Mutations reactive-site area human pancreatic secretory trypsin inhibitor confer a-thrombin factor Xa inhibitory activities

Mutations transmembrane glycoprotein Mason-Pfizer monkey virus - loss SU-TM association effects infectivity

Mutator Effects in Escherichia coli Caused by the Expression of Specific Foreign Genes

Mutator Phenotype Resulting from DNA Polymerase IV Overproduction in Escherichia coli: Preferential Mutagenesis on the Lagging Strand

Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants

Mutator Phenotype of MUTYH-null Mouse Embryonic Stem Cells

Mutator and Antimutator Effects of the Bacteriophage P1 hot Gene Product

Mutator phenotype in a mutant of S49 mouse T-lymphoma cells with abnormal sensitivity to thymidine

Mutator phenotype of Werner syndrome is characterized by extensive deletions

Mutatox test. test monitoring environmental genotoxic agents

Mute Swans Impact Submerged Aquatic Vegetation Chesapeake Bay

Muting bark

Mutual Binding Inhibition Tetrodotoxin Saxitoxin Their Binding Protein Plasma Puffer Fish, Fugu pardalis

Mutual Control Membrane Fission Fusion Proteins

Mutual Effects of Translation Initiation Factors in Binding to the IRES of the Encephalomyocarditis Virus RNA

Mutual Information Protein Multiple Sequence Alignments Reveals Two Classes Coevolving Positions

Mutual Interactions of Sulfate, Oxalate, Citrate, and Phosphate on Synthetic and Natural Allophanes

Mutual Interdependence MSI1 (CAC3) YAK1 Saccharomyces cerevisiae

Mutual Interference between Genomic RNA Replication and Subgenomic mRNA Transcription in Brome Mosaic Virus

Mutual Interference of Adenovirus Infection and myc Expression

Mutual Interference Pheromone Traps Within Trap Lines Captures Boll Weevils (Coleoptera - Curculionidae)

Mutual Regulation of Protein-tyrosine Phosphatase 20 and Protein-tyrosine Kinase Tec Activities by Tyrosine Phosphorylation and Dephosphorylation

Mutual Relationships Between Soils Biological Carrier Systems

Mutual Targeting of Mediator and the TFIIH Kinase Kin28

Mutual activation of Ets-1 and AML DNA binding by direct interaction of their autoinhibitory domains

Mutual benefits associations breeding non-breeding White-fronted Geese Anser albifrons

Mutual effects of proton and sodium chloride on oxygenation of liganded human hemoglobin. Oxygen affinities of the a and b subunits

Mutual entrainment and electrical coupling as mechanisms for synchronous firing of rabbit sino-atrial pace-maker cells

Mutual inspiration

Mutual orientation L7/L12 dimers 50S ribosome Escherichia coli measured energy transfer covalently bound probes

Mutual phase-locking microwave spin torque nano-oscillators

Mutual poaching - U.S. Canada eye other's salmon

Mutual prey fish humans. comparison biomass consumed bluefish, Pomatomus saltatrix, harvested fisheries

Mutual regulation between B7-1 (CD80) expressed on T cells and IL-4

Mutual regulation metabotropic glutamate type 1a receptor caveolin proteins - traffick constitutive activity

Mutual regulation of the transcriptional activator NF-kB and its inhibitor, IkB-a

Mutual relationships between chromogranins A and B and gastrin in individual gastrin cells

Mutual repression between msh and lro-C is an essential component of the boundary between body wall and wing in Drosophila

Mutual stabilization detergent tolerant subtilisin heat stable Streptomyces subtilisin inhibitor complex structure

Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB

Mutualism community organization (book review)

Mutualism carnivorous purple pitcher plant inhabitants

Mutualisms Aquatic Community Structure - The Enemy My Enemy My Friend

Mutualistic interactions freshwater modular systems molluscan components

Mutually Exclusive Glomerular Innervation by Two Distinct Types of Olfactory Sensory Neurons Revealed in Transgenic Zebrafish

Mutually Exclusive Splicing Insect Dscam Pre-mRNA Directed Competing Intronic RNA Secondary Structures

Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite

Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes

Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger

Mutually exclusive binding of peptide and invariant chain to major histocompatibility complex class II antigens

Mutually exclusive exon splicing of the cardiac calcium channel a1 subunit gene generates developmentally regulated isoforms in the rat heart

Mutually exclusive exon splicing of type III brain sodium channel a subunit RNA generates developmentally regulated isoforms in rat brain

Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development

Mutually exclusive expression of the Strongylocentrotus purpuratus Spec1 gene and its Lytechinus pictus homologue in cells of hybrid embryos

Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-mNR enhancer repressor. Implications for regulation of immunoglobulin heavy chain expression

Mutually exclusive splicing of calcium-binding domain exons in chick a-actinin

Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes

Mutually repressive interactions between the gap genes giant and Kruppel define middle body regions of the Drosophila embryo

Mx genes show weaker primary answer virus interferon-regulated genes

Mx-dependent resistance influenza viruses stimulated mouse interferons

Mxil is a repressor of the c-myc promoter and reverses activation by USF

Mxr1p, a Key Regulator of the Methanol Utilization Pathway and Peroxisomal Genes in Pichia pastoris

My 43 monoclonal antibody reacts human myeloid cells inhibits monocyte IgA binding triggers role

My 5 Steps To Cow/Calf Survival

My Appalachia

My Brief Encounter with the Phosphoinositides and IP3

My Connecticut garden (book review)

My Fabulous, Virtuous Vacation

My Life Science

My Love Affair With American Fruit Grower

My Love Affair with Insulin

My Money Is Greener Than Your Money - Socially responsible investing major Wall Street trend. But real question - Can dough youre virtuous?

My O'Myeloid, a tale of two lineages

My affair with the JAP<